patients diagnosed as having chronic mercury toxicity (CMT), 32.3% had severe fatigue, 88.8% had memory loss, and 27.5% had depression …. Removal of amalgam mercury fillings when combined with appropriate treatment resulted in a significant symptom reduction (p<0.001) to levels reported by healthy subjects …. This research supports a correlation between a genetic inability to eliminate mercury when the APO- E4 allele has been inherited and an increased incidence of common symptoms and signs of chronic mercury toxicity …. In our experience and that of other investigators, most patients have reached middle-age before presenting with CMT
